2,3,7,8 Tetrachlorodibenzo-para-dioxin:
Immunosuppresant Effects: In vitro studies on T-cells

Phillip Song

Four sets of in vitro experiments done on isolated cells suggest that the proliferation of three populations of immune cells: fetal blood lymphocytes, adult peripheral blood lymphocytes, and cytotoxic T-lymphocytes lymphomas (CTLLs) are inhibited by the addition of 2,3,7,8 tetrachlorodibenzo-p-dioxin. Depression of proliferation rates suggests that T-cells are sensitive to TCDD exposure, however the extent of this inhibition varied depending on a variety of factors including cell culture composition, age of TCDD, and type of blood donor. In particular, the effects of TCDD were found to be extremely sensitive to the method of dose delivery, such that significant differences in effects were observed when the organic composition of the delivery vehicle was changed.